Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PhysiologyJournal of Applied PhysiologyPeer-reviewed10 citations
- PhysiologyGeroSciencePeer-reviewed
Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats
Chengyun Tang, Huawei Zhang, Jane J. Border…·Fan Fan
This study examines the structural and mechanical properties of the middle cerebral artery in Dusp5 KO rats, finding limited structural changes but enhanced myogenic tone, suggesting Dusp5's role in hemodynamics and cognition is enzyme-driven.
5 citations - PhysiologyAmerican Journal of Physiology-Endocrinology and MetabolismPeer-reviewed
17α-estradiol Alleviates High-Fat Diet-Induced Inflammatory and Metabolic Dysfunction in Skeletal Muscle of Male and Female Mice
Matthew P. Bubak, Shivani N. Mann, Agnieszka Borowik…·Benjamin F. Miller
This study shows 17α-estradiol improves metabolic and inflammatory outcomes in skeletal muscle of male mice but not females on a high-fat diet.
14 citations - PhysiologyJournal of Experimental BotanyPeer-reviewed
Physiological adaptation to high irradiance in duckweeds depends on light habitat niche and is ecotype and species-specific.
Kellie E. Smith, Laura Cowan, Beth Taylor…·Erik Harry Murchie
The paper examines how duckweed ecotypes and species adapt to high light conditions, finding species-specific physiological responses and ecotype-specific acclimation abilities.
22 citations - PhysiologybioRxivPreprint
TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility
Pradeep Rajasekhar, Simona Carbone, Stuart T. Johnston…·Daniel P. Poole
This paper identifies TRPV4-expressing cell types in the colon and shows limited involvement of TRPV4 in colonic motility.
- PhysiologyAmerican Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyPeer-reviewed
Immunohistochemical and ultrastructural characterization of the inner ear epithelial cells of splitnose rockfish (Sebastes diploproa)
Garfield T. Kwan, Leonardo Rodrigues de Andrade, Kaelan J. Prime, Martín Tresguerres
This study characterizes the inner ear epithelial cell types and protein expression in splitnose rockfish to understand otolith biomineralization and its sensitivity to environmental factors.
DOI 10.1152/ajpregu.00223.2023 - PhysiologyJournal of Biological ChemistryPeer-reviewed
MFGE8 inhibits insulin signaling through PTP1B
Ritwik Datta, Dibyanti Mukherjee, Michael J. Podolsky…·Kamran Atabai
This study shows MFGE8 inhibits insulin signaling by promoting PTP1B binding to and dephosphorylation of IR{beta}, reducing glucose uptake, and identifies a correlation between serum MFGE8 levels and insulin resistance in humans.
10 citations - PhysiologyActa Pharmaceutica Sinica BPeer-reviewed
A Medium Chain Fatty Acid, 6-hydroxyhexanoic acid (6-HHA), Protects Against Obesity and Insulin Resistance
Sara C. Sebag, Meihua Hao, Qingwen Qian…·Ling Yang
This paper identifies 6-hydroxyhexanoic acid (6-HHA), a medium chain fatty acid from Streptococcus gordonii, as a compound that reduces obesity and insulin resistance in mice fed a high-fat diet.
24 citationstop 3% - PhysiologyEuropean Journal of Applied PhysiologyPeer-reviewed
Single-session measures of quadriceps neuromuscular function are reliable in healthy females and unaffected by age
Steven J. O’Bryan, Danielle Hiam, Séverine Lamon
This study assesses the inter-session reliability of quadriceps neuromuscular function measures in healthy females across age, showing excellent reliability and minimal systematic bias.
7 citations - PhysiologyFrontiers in HematologyPeer-reviewed
Vhl deletion in Dmp1-expressing cells alters MEP metabolism and promotes stress erythropoiesis
Janna Emery, Betsabel J Chicana, Hanna Taglinao…·Jennifer O. Manilay
This study shows that deleting Vhl in Dmp1-expressing cells increases stress erythropoiesis by altering MEP metabolism and inducing hypoxia-like responses.
1 citation - PhysiologybioRxivPreprint
Intestinal flow rates, absorption of felodipine from the small intestine and attributes of chyme collected at midgut from Labradors
Steffen M. Diebold, In memory of Mia Wilsson-Rahmberg
This study investigates gastrointestinal hydrodynamics in Labradors, examines intestinal fluid attributes, and assesses felodipine absorption influenced by hydrodynamics.
DOI 10.1101/2024.01.05.574377 - PhysiologyBiology OpenPeer-reviewed
The influence of carbon dioxide on cerebral metabolism and oxygen consumption: combining multimodal monitoring with dynamic systems modelling
David Highton, Matthew Caldwell, Ilias Tachtsidis…·Chris E. Cooper
This study combines multimodal monitoring with dynamic systems modeling to investigate how hypercapnia affects cerebral metabolism and oxygen consumption in humans.
- PhysiologyScientific ReportsPeer-reviewed
Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice
Leonardo Vinícius Monteiro de Assis, Lisbeth Harder, José Thalles Lacerda…·Henrik Oster
This study investigates how thyroid hormone levels affect liver circadian transcriptome rhythms in mice, identifying 516 genes as molecular markers of liver TH state.
14 citations - PhysiologyeLifePeer-reviewed
Involvement of TRPV4 in temperature-dependent perspiration in mice
Makiko Kashio, Sandra Derouiche, Reiko U. Yoshimoto…·Makoto Tominaga
This study shows TRPV4 is involved in temperature-dependent perspiration in mice through interactions with ANO1, and its expression is higher in normohidrotic AIGA patients.
11 citations - PhysiologybioRxivPreprint
Dietary methionine/choline deficiency affects behavioural and molecular circadian rhythms
Ben Saer, George Taylor, Andrew Hayes…·Jean‐Michel Fustin
This study shows that dietary methionine/choline deficiency disrupts circadian rhythms and gene expression in mice, with effects dependent on circadian time.
3 citations - PhysiologyPhysiology & BehaviorPeer-reviewed
Brainstem astrocytes regulate breathing and may affect arousal state in rats
Mitchell Bishop, Shahriar SheikhBahaei
This study shows that astrocytes in the preBotzinger complex regulate breathing and arousal in rats, with inhibited signaling linked to calmness and enhanced signaling linked to arousal.
8 citations - PhysiologyPLoS ONEPeer-reviewed
Effects of surface geometry on light exposure, photoacclimation and photosynthetic energy acquisition in zooxanthellate corals
Tomás López-Londoño, Susana Enríquez, Roberto Iglesias‐Prieto
This study examines how coral surface geometry affects light exposure, photoacclimation, and photosynthetic energy acquisition in zooxanthellate corals.
- PhysiologyNature CommunicationsPeer-reviewed
Hijacking of internal calcium dynamics by intracellularly residing rhodopsins
Àna-Sofia Eria-Oliveira, Mathilde Folacci, Anne‐Amandine Chassot…·Michel Vivaudou
The paper shows that viral channelrhodopsins (VCR1s) induce intracellular calcium release upon illumination, enabling light-controlled muscle contraction in tadpoles, suggesting a new optogenetic tool.
- PhysiologyProgress in brain researchPeer-reviewed
Identifying HRV and EEG correlates of well-being using ultra-short, portable, and low-cost measurements
Cédric Cannard, Arnaud Delorme A, Helané Wahbeh
The paper evaluates EEG and HRV metrics from portable devices to identify correlates of well-being in real-world settings, finding associations between eudaimonic well-being and HRV metrics, and physical well-being and EEG asymmetry.
5 citationstop 1% - PhysiologyFunctionPeer-reviewed
Intrinsic skeletal muscle function and contraction-stimulated glucose uptake do not vary by time-of-day in mice
Liam S. Fitzgerald, Shannon N. Bremner, Samuel R. Ward…·Simon Schenk
This study shows that intrinsic skeletal muscle function and contraction-stimulated glucose uptake in mice do not vary across the 24-hour circadian cycle.
5 citations