Leonardo Rodrigues de Andrade

The paper presents the structure of an RNA polymerase ribozyme complex bound to RNA substrates, revealing its catalytic mechanism and structural similarity to polymerase proteins.

This study identifies Pcdh20 as a POU2F3 target gene essential for tuft cell microvillus structure, showing its role in maintaining microvillar rigidity and organization.

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

This study identifies Fhod3 as a key regulator of actin dynamics in the cuticular plate, linking its dysregulation to progressive high-frequency hearing loss in mice.

This study shows that calcium signaling in oligodendrocytes is critical for shaping myelin sheath morphology during myelination in the developing mouse CNS.

The paper identifies endosomal sorting pathways that drive the formation of mutant prion endoggresomes and shows that inhibiting this process can reduce axonal dysfunction.