Pradeep Rajasekhar

The paper performs proteomic analysis of megakaryocytes in MPN patients and identifies disease-specific proteomic signatures.

This study identifies dysregulated epithelial cell death signaling in inflammatory bowel disease, showing it persists during remission despite therapy.

SpatialBench evaluates spatial transcriptomics platforms using a mouse spleen model, finding consistent biological signals but varying resolution across technologies.

This study examines the impact of diabetes on the colonic mucus layer and goblet cells in db/db mice, finding a thinner mucus layer and goblet cell hyperplasia.

This study investigates how Plasmodium falciparum bypasses the erythrocyte cytoskeleton during invasion by analyzing the timing of cytoskeletal disassembly and apical organelle release using lattice light sheet microscopy.

The paper introduces GAT, a tool for automated analysis of enteric neurons in gut tissue images, improving accuracy and throughput over manual methods.

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

The paper benchmarks spatial transcriptomics technologies using a multi-sample dataset from mouse spleen tissue, finding improved data quality with probe-based capture methods and CytAssist.

This paper identifies TRPV4-expressing cell types in the colon and shows limited involvement of TRPV4 in colonic motility.

The paper introduces CLIJ-assistant, a tool that enables interactive GPU-accelerated image processing and cross-platform code generation for bio-image analysis.