Discover, rate, and discuss biology preprints.

This study shows that α-MSH protects against cardiac remodeling by activating MC5-R in cardiomyocytes, suggesting potential therapeutic use of its analogs in heart failure.

This study shows insulin-like peptides (ILPs) in Anopheles stephensi regulate ovarian ecdysteroid production, which is necessary for yolk deposition into oocytes.

This study examines how brood size manipulation affects mitochondrial metabolism and ROS production in great tit chicks, finding no significant long-term effects but noting size-related metabolic differences.

This study examines Ca2+ dynamics and energy metabolism in a transgenic mouse model of the PLN-R14del mutation before cardiomyopathy onset, finding altered mitochondrial function and ER-stress activation.

This study shows that dehydration reduces the postprandial thermophily in pythons, indicating a trade-off between body temperature regulation and water balance.

This study shows that adventitial macrophage accumulation in mesenteric arteries with IBD impairs perivascular nerve function, particularly sensory vasodilation, which is reversed by macrophage depletion.

This study evaluates the agreement between the KuduSmart(R) device and ventilated capsule for measuring sweat responses during heat stress and exercise, finding acceptable agreement for some metrics but not others.

This study examines how gradual ovarian failure in a mouse menopause model affects single muscle fiber contractility, finding no significant differences in force per CSA but altered calcium sensitivity in specific muscles.

This study investigates the mechanisms of right ventricular stiffening in pulmonary hypertension using a large animal model, finding that myocardial stiffness is the primary contributor.

This paper introduces an HPC-based method to improve 2D-Dwell-Time analysis of ion channel gating, enabling reliable extraction of Markov models from noisy data.

This study shows that blocking IL-1β early after pressure-overload reduces left ventricular dilation but not heart failure, while late blocking reduces lymphangiogenesis without worsening fibrosis.

This study shows that intestinal Surf4 deficiency reduces lipid absorption, secretion, and metabolism in mice, leading to weight loss and altered lipid levels.

The study tests whether parasitism reduces thermal limits in copepods but finds no such effect, suggesting host life history may influence environmental sensitivity.

This study uses RNAi to knock down two orphan GPCRs in Aedes aegypti, finding reduced fecundity, suggesting their role in reproduction.

This study shows that dietary calcium affects calcium content and transporter mRNA expression in mosquito Malpighian tubules, with dynamic changes during blood feeding.

This study shows that short-term high fat diet feeding in mice reduces norepinephrine-induced Ca2+ signaling in hepatocytes and intact liver, suggesting impaired PLC activity contributes to early NAFLD pathogenesis.

This study examines how menstrual cycle phases affect motor unit function in vastus lateralis muscle, finding reduced firing rates of low threshold motor units during high progesterone phases without affecting neuromuscular performance.