Discover, rate, and discuss biology preprints.

This study shows Kir2.1 channels link flow-induced signaling to Piezo1/PI3K/Akt1 pathways, restoring flow-induced vasodilation in Kir2.1-deficient endothelium.

This study compares a data-driven designed running shoe to existing state-of-the-art models, finding the new shoe improves running economy across all tested runners.

This study shows that body-weight-matched bleomycin-induced ALI in rats reveals sex-specific pathophysiological differences, with males showing worse hypoxemia and distinct molecular responses compared to females.

This study examines the effects of restricting individual branched-chain amino acids on Alzheimer's disease progression in 3xTg mice, finding sex-specific cognitive and metabolic benefits.

This study shows that sleeve gastrectomy in lean mice improves metabolic health and protects against future obesity without weight loss.

This study uses multi-omics profiling to identify molecular mechanisms contributing to progressive right ventricular dysfunction in pigs.

This study shows that dietary glutamine restriction reduces atherosclerotic plaque rupture mortality by promoting fibrotic smooth muscle cell phenotypes in mice.

This study examines how aerobic exercise affects blood pressure, cardiac function, and the AGEs/RAGE-p38 MAPK-NF-κB pathway in SHR rats, finding that exercise reduces blood pressure and cardiac damage by inhibiting this pathway.

This study shows setmelanotide reduces opioid-induced respiratory depression in mice without reversing analgesia.

This study shows that intramuscular adipose tissue (IMAT) accumulation worsens limb function in PAD/CLTI, and reducing IMAT improves muscle strength and work output in mice.

The paper develops a reduced-order model for plasma transport in tumors by integrating CFD simulations with a RAD model, showing improved accuracy with EHD effects.

The paper shows immune cells regulate circulating adipocyte extracellular vesicle levels by clearing EVs, with reduced clearance in obesity leading to increased circulating adipoEVs.

This study identifies pulmonary microvascular rarefaction as a novel mechanism in heart failure, linking it to impaired gas exchange and worsened cardiac function.

The paper investigates NRAC's role in reciprocal adipose-heart regulation of fatty acid metabolism across nutritional states using human and mouse data.

The paper identifies a loss-of-function variant in GFRAL associated with increased alcohol consumption in humans and shows GDF15 reduces alcohol drinking in mice.

The paper quantifies seasonal NSC dynamics in a temperate pine forest, finding that soluble sugars drive carbon balance through redistribution rather than storage changes.

This study shows that reversing DNA methylation at the Trpm7 promoter in carotid bodies of obese mice reduces hypertension by decreasing Trpm7 expression and nerve activity.

This study investigates tissue-specific regulation of PNPLA3 in mice, showing feeding increases hepatic PNPLA3 while cold exposure boosts it in brown adipose tissue through post-transcriptional mechanisms, linking it to lipid remodeling in response to metabolic stress.

This study shows that loss of bone marrow β1/β2-adrenergic receptors protects against diet-induced obesity by altering gut microbiota composition and lipid metabolism.