Discover, rate, and discuss biology preprints.

This study shows that cellular senescence contributes to Doxorubicin-induced vascular endothelial dysfunction and that senolytic treatment can prevent this dysfunction.

This study uses dynamic proteome profiling to show that resistance exercise improves proteostasis in older human skeletal muscle by increasing mitochondrial protein turnover and restoring proteomic imbalances.

This study examines the relationship between body fat percentage and postprandial metabolic flexibility in young adults, finding that higher body fat is associated with greater metabolic flexibility during an OGTT.

This study shows that the circadian intraocular pressure (IOP) rhythm in rats is driven by sympathetic efferents from the superior cervical ganglion, not local oscillators or humoral signals.

This study finds that hepatic β-Klotho is downregulated in hypertensive SHR, suggesting peripheral FGF-21 resistance links metabolic dysfunction to hypertension.

This study shows Akt1 nitration promotes PAH by enhancing EndMT and vascular proliferation, using a nitration-resistant mouse model.

This study modifies a computational model of hiPSC-CMs to compare their excitation properties with hV-CMs under various conditions and finds hiPSC-CMs are more excitable due to their depolarized resting potential and intrinsic automaticity.

This study shows that PDCD4 depletion in myotubes increases myofibrillar protein accumulation but reduces protein synthesis, linked to metabolic changes and reduced ATP levels.

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.

This study identifies saITP and Gyc76C as key regulators of water balance in Drosophila hindgut via a neuroendocrine axis.

This study investigates whether mastication improves sustained attention in rested healthy participants during short cognitive tasks, finding no significant improvements.

This study shows that the vitamin D receptor is essential for metabolic health after sleeve gastrectomy in mice, affecting insulin sensitivity, white adipose tissue function, and inflammation, with similar findings in human patients.

The paper investigates how defective cardiolipin remodeling in Barth Syndrome affects pancreatic islet function and metabolism, finding improved glucose tolerance and compensatory metabolic adaptations in a mouse model.

This study shows warming reshapes PFAS tissue concentrations and distribution, influencing fish energy-allocation trade-offs.

This study examines changes in S1PR expression and endothelial barrier/inflammatory markers in human brain endothelial cells after ischemia-reperfusion injury, finding increased S1PR1 expression and potential therapeutic implications.

This study investigates how missense mutations in the CTD of Nav1.5 affect gating properties, revealing distinct effects on inactivation and activation.

This study identifies serine dehydratase (Sds) as a regulator of serine and sphingolipid metabolism, showing that its deletion improves skin repair in diabetic mice.

This study shows that touch perception interacts with dietary restriction to modulate lifespan in C. elegans through bioamine and neuroendocrine signaling.

This study shows that DACOS, a chitosan oligosaccharide, enhances plant defense against spider mites by inducing systemic resistance and repellency without direct acaricidal effects.

This study shows that morning caffeine ingestion improves neuromuscular performance in females, matching evening levels by increasing peak force and time to exhaustion.