Cilia to basement membrane signalling is a biomechanical driver of autosomal dominant polycystic kidney disease
M. Mazloum, B. Lapin, A. Viau, R. Alghamdi, M. Burtin, P. Houillier, L. Cheval, G. Crambert, A. Aka, E. W. Kuehn, C. Cohen, S. Descroix, T. Busch, M. Koettgen, S. Garbay, , F. Bienaime
This study identifies biomechanical changes in the tubular basement membrane as drivers of cyst formation in ADPKD, linking cilia and polycystin-1 function.
bioRxiv · Jun 6, 2024 · PreprintPhysiology