G. Crambert

Cilia to basement membrane signalling is a biomechanical driver of autosomal dominant polycystic kidney disease

This study identifies biomechanical changes in the tubular basement membrane as drivers of cyst formation in ADPKD, linking cilia and polycystin-1 function.

Low exposure to lithium does not induce nephrogenic diabetes insipidus but microcystic dilations of collecting ducts in a long-term rat model

This study shows that low lithium exposure in rats causes microcystic dilations of collecting ducts without inducing nephrogenic diabetes insipidus.

GDF15 mediates renal cell plasticity in response to potassium depletion

This study shows that GDF15 mediates renal cell plasticity in response to potassium depletion by regulating intercalated cell numbers and K+ retention.

Claudin-4, a core component of the tight-junctional complex along the collecting system, is induced in nephrotic syndrome

This study shows claudin-4 expression increases in nephrotic syndrome, suggesting a shift from transcellular to paracellular chloride transport in the kidney collecting system.

A new variant of ASIC2 mediates sodium retention in nephrotic syndrome

The paper identifies a truncated variant of ASIC2b responsible for sodium retention in idiopathic nephrotic syndrome, independent of ENaC and aldosterone.