Role of the Topoisomerase IIα Chromatin Tether domain in Nucleosome Binding & Chromosome Segregation
S. Sundararajan, H. Park, S. Kawano…·Y. Azuma
This study shows that TopoII's Chromatin Tether domain binds methylated histone H3K27me3 to prevent anaphase ultra-fine bridges, ensuring proper chromosome segregation.