Cardiomyocyte mechanical memory is regulated through the talin interactome and DLC1 dependent regulation of RhoA
E. Marhuenda, I. Xanthis, P. Pandey, A. Azad, M. Richter, D. Pavlovic, K. Gehmlich, G. Faggian, E. Ehler, J. Levitt, S. Ameer-Beg, T. Iskratsch
The paper identifies DLC1's role in regulating RhoA activity through the talin interactome, linking mechanical memory to cardiac phenotype changes.
bioRxiv · Jul 19, 2023 · PreprintCell Biology