T. Iskratsch

Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes

This study shows that overexpression of SAS-6 promotes ciliogenesis and cell invasion through YAP/TAZ pathway activation, linked to poor cancer prognosis.

Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI.

This paper shows that fibronectin stimulates vascular smooth muscle cells to secrete collagen VI-rich extracellular vesicles that modulate cell adhesion and directionality by forming focal adhesions in the extracellular matrix.

Cardiomyocyte mechanical memory is regulated through the talin interactome and DLC1 dependent regulation of RhoA

The paper identifies DLC1's role in regulating RhoA activity through the talin interactome, linking mechanical memory to cardiac phenotype changes.

Myonuclear alterations associated with exercise are independent of age in humans

This study shows that exercise-induced changes in myonuclear shape and stiffness occur independently of age in humans, potentially preserving muscle function across the lifespan.

Photoelectrochemical imaging of action potentials for single cardiomyocytes through contact force manipulation of organoids

This paper introduces a method to monitor action potentials in cardiomyocytes using photoelectrochemical imaging with contact force control, validated with drugs and showing electrophysiological changes.

Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM

This study investigates how integrin-ligand combinations affect cardiomyocyte adhesion, traction forces, and mechanosignalling in healthy and fibrotic ECM environments.

Lem2 is essential for cardiac development by maintaining nuclear integrity

This study shows Lem2 is essential for cardiac development by maintaining nuclear integrity, as its absence leads to DNA damage, nuclear rupture, and apoptosis in mouse hearts.

Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching and cofilin dependent podosome formation

This study shows that matrix stiffness and blood pressure together drive vascular smooth muscle cell phenotypic switching and cofilin-dependent podosome formation in atherosclerosis.

Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing.

This study shows that glioma stem cells exhibit optimal migration at specific matrix stiffness, mediated by MGAT5-dependent N-glycan branching.