Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM
A. B. Loveland, E. Svidritskiy, D. Susorov…·A. A. Korostelev
This study shows that poly-PR and poly-GR DPR proteins inhibit ribosome peptidyl-transferase activity by blocking the polypeptide tunnel, as revealed by cryo-EM structures.