Ring Finger Protein 213 Assembles into a Sensor for ISGylated Proteins with Antimicrobial Activity
F. Thery, L. Martina, C. Asselman, H. Repo, Y. Zhang, K. Sedeyn, G. D. Moschonas, C. Bredow, Q. W. Teo, J. Zhang, M. Vessely, K. Leandro, D. Eggermont, D. De Sutter, K. Boucher, , F. Impens
This study identifies RNF213 as an ISG15-interacting sensor that detects ISGylated proteins and exhibits broad antimicrobial activity against multiple pathogens.
bioRxiv · Jun 3, 2021Cell Biology