Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome
A. Bitto, A. S. Grillo, I. B. Stanaway, B. M. G. Nguyen, K. Ying, H. Tung, K. Smith, N. Tran, G. Velikanje, S. Urfer, J. M. Snyder, E.-B. Kayser, L. Wang, D. L. Smith, J. W. Thompson, , M. Kaeberlein
This study shows acarbose reduces symptoms and improves survival in a mouse model of Leigh Syndrome, independent of mTOR inhibition, and suggests gut microbiome modulation may impact mitochondrial disease.
bioRxiv · Jan 31, 2022 · PreprintBiochemistry