D. L. Smith

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence

The paper characterizes the BREX system in Salmonella, determines the structure of PglX, and shows how rational engineering expands phage targeting and host motif methylation.

Reduced Telomerase Interaction with Telomeres Alters Meiotic Chromosome Motion and Gamete Viability

This study shows that reduced telomerase interaction with telomeres in yeast affects meiotic chromosome motion and gamete viability by altering recombination and cytoskeletal forces.

Small but significant genetic differentiation among populations of Phyllachora maydis in the midwestern United States revealed by microsatellite (SSR) markers.

This study uses SSR markers to analyze genetic differentiation in Phyllachora maydis populations across the Midwest U.S., finding significant but low genetic differentiation and evidence of sexual recombination.

Uncovering the Environmental Conditions Required for Phyllachora maydis Infection and Tar Spot Development on Corn in the United States for Use as Predictive Models for Future Epidemics

Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome

This study shows acarbose reduces symptoms and improves survival in a mouse model of Leigh Syndrome, independent of mTOR inhibition, and suggests gut microbiome modulation may impact mitochondrial disease.

Principled simulation of agent-based models in epidemiology

The paper introduces a method to approximate stochastic epidemic models using agent-based simulations, improving speed while converging to exact results in limiting cases.

A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism

Measuring the accuracy of gridded human population density surfaces: a case study in Bioko Island, Equatorial Guinea

This paper evaluates population density maps using census data from Bioko Island, finding that LandScan best captures urban areas, HRSL performs well in rural areas, and WorldPop is less accurate overall.

Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female Mice

This study shows canagliflozin extends lifespan in male but not female mice, likely by reducing peak glucose levels, similar to acarbose.

Vector bionomics and vectorial capacity as emergent properties of mosquito behaviors and ecology

The paper develops a new simulation framework to model mosquito behavior and ecology, showing vectorial capacity emerges from interactions between behavioral algorithms and resource landscapes.

Modelling the distribution of Aedes aegypti and Aedes albopictus using climate, host density and interspecies competitive effects

The paper develops a predictive model for the spatial distribution of Aedes aegypti and Aedes albopicti in Florida using climate, host density, and competitive interactions, achieving high validation accuracy.

Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda

This study quantifies household and spatial variation in malaria vector exposure using Bayesian modeling in three Ugandan sites, identifying hotspots linked to environmental factors and seasonal changes.