BiochemistrybioRxivPreprint
Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome
A. Bitto, A. S. Grillo, I. B. Stanaway…·M. Kaeberlein
This study shows acarbose reduces symptoms and improves survival in a mouse model of Leigh Syndrome, independent of mTOR inhibition, and suggests gut microbiome modulation may impact mitochondrial disease.
DOI 10.1101/2022.01.31.478591