Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior
T. Khan, T. Kandola, J. Wu, E. Ketter, S. Venkatesan, J. J. Lange, A. Rodriguez Gama, A. Box, J. R. Unruh, M. Cook, R. Halfmann
The paper quantifies nucleation in living cells using DAmFRET and shows that kinetic barriers influence prion-like phase behavior and protein aggregation.
bioRxiv · Apr 19, 2018Biophysics