N. Rohner

Establishing Primary and Stable Cell Lines from Frozen Wing Biopsies for Cellular, Physiological, and Genetic Studies in Bats

This paper develops a protocol for isolating and culturing primary fibroblasts from frozen bat wing biopsies and establishes stable cell lines for genetic and physiological studies.

Potential role of microRNAs in regulating transcriptional profile, and sculpting development and metabolism in cavefish.

This study identifies 683 miRNAs in cavefish, revealing their role in regulating development and metabolism through differential expression and pathway involvement.

Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity

The paper identifies FATP2 as a conserved target for preventing starvation-induced liver atrophy by reducing fatty acid uptake in cavefish and other species.

The prevalence of copy number increase at multiallelic CNVs associated with cave colonization in Mexican tetra (Astyanax mexicanus)

The paper identifies copy number variants associated with cave adaptation in Mexican tetra by comparing surface and cave populations.

Sugar assimilation underlying dietary evolution of Neotropical bats

This study examines sugar assimilation in Neotropical bats, revealing metabolic adaptations to different diets through glucose tolerance tests, genome analysis, and gene expression studies.

3D spheroid culturing of Astyanax mexicanus liver-derived cell lines recapitulates distinct transcriptomic and metabolic states of in vivo tissue environment.

This study uses 3D spheroid culturing to model metabolic and transcriptomic states of Astyanax mexicanus liver cells, revealing cave-specific metabolic signatures.

The Mexican Cavefish Mount a Rapid and Sustained Regenerative Response Following Skeletal Muscle Injury

The paper investigates the regenerative response of skeletal muscle in Mexican cavefish following injury, focusing on satellite cell behavior and regeneration mechanisms.

Circadian rhythm disruption is associated with skeletal muscle dysfunction within the blind Mexican Cavefish

This study investigates circadian-regulated gene expression in skeletal muscle of cavefish and surface fish to determine if muscle dysfunction is due to circadian disruption.

Microbial diversity ensures the stability of carbon cycling processes under increasing temperature in model soils

This study shows that microbial diversity in soils helps maintain stable carbon cycling under temperature changes, with lower diversity leading to greater instability in carbon use efficiency at higher temperatures.

Selection-driven trait loss in independently evolved cavefish populations

This study shows that selection, not mutation, drives repeated trait evolution in cavefish, with genes having longer coding regions being more likely to undergo repeated adaptation.

Liver-derived cell lines from cavefish Astyanax mexicanus as an in vitro model for studying metabolic adaptation

The paper develops liver-derived cell lines from cavefish Astyanax mexicanus to study metabolic adaptation and provides their characterization.

Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility

This paper shows cavefish have reduced muscle mass and contractility but increased muscular endurance due to metabolic reprogramming involving glycogen utilization.

Hybridization underlies localized trait evolution in cavefish

This study shows hybridization contributes to localized trait evolution in cavefish by analyzing genomic and phenotypic variation in Chica cave pools.

Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity.

This study shows that cavefish enhance lipogenesis via upregulated Pparγ to store more fat, aiding adaptation to nutrient scarcity.

Image3C: a multimodal image-based and label independent integrative method for single-cell analysis

Image3C enables single-cell analysis without species-specific reagents by using image-based clustering and CNN integration to detect cellular composition changes.

Pleiotropic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish

This study identifies oca2 as a gene with pleiotropic effects that contributes to both albinism and sleep loss in cavefish.

Repeated evolution of circadian clock dysregulation in cavefish populations

This study shows that cavefish populations have independently evolved circadian clock dysregulation, with reduced transcriptome rhythmicity and sleep reduction linked to specific gene mutations.

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia

The paper shows that loss of Hexokinase 2 in adipose tissue due to high fat diet leads to hyperglycemia through systemic glucose homeostasis disruption.

Adaptation to low parasite abundance affects immune investment strategy and immunopathological responses of cavefish

This study shows that cavefish, adapted to low parasite abundance, have a more sensitive immune system with reduced proinflammatory responses and shifted immune investment to adaptive immunity.

The role of gene flow in rapid and repeated evolution of cave related traits in Mexican tetra, Astyanax mexicanus

This study shows that gene flow plays a significant role in the rapid evolution of cave-related traits in Mexican tetra, challenging the classic hypothesis of disuse and drift.

Insulin resistance in cavefish as an adaptation to a nutrient-limited environment

This study shows cavefish have insulin resistance due to a mutation in the insulin receptor, which may confer advantages in nutrient-limited environments despite negative effects seen in humans.