L. Bauer

Target-based discovery of a broad spectrum flukicide

The paper identifies a new flukicide, BZQ, effective against both Fasciola and Schistosoma species by targeting a conserved TRPMPZQ ion channel.

Dissecting MPXV neurotropism and host antiviral signaling using human stem cell-based models

This study investigates MPXV neurotropism and antiviral signaling in CNS cells using human stem cell-derived models, finding that glial cells are more susceptible and exhibit reduced type I IFN responses.

The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells

This study shows that endothelial cells are abortively infected by influenza A virus and contribute to systemic inflammation through increased cytokine secretion in co-cultures with infected epithelial cells.

Differences in neuroinflammation in the olfactory bulb between D614G, Delta and Omicron BA.1 SARS-CoV-2 variants in the hamster model

The paper compares neuroinflammation in the olfactory bulb of hamsters infected with D614G, Delta, and Omicron BA.1 SARS-CoV-2 variants, finding differences in neuroinvasion and neurovirulence.

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

This study identifies fluoxetine as an inhibitor of the enterovirus 2C AAA+ ATPase, revealing its mechanism of action through structural and functional analyses.

Replication kinetic, cell tropism and associated immune responses in SARS-CoV-2 and H5N1 virus infected human iPSC derived neural models

This study compares SARS-CoV-2 and H5N1 virus replication, cell tropism, and immune responses in human iPSC-derived neural cultures, finding sparse SARS-CoV-2 infection with immune activation versus efficient H5N1 replication.

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

This study develops a platform combining deep learning and high-content imaging to identify disease-specific phenotypes in Parkinson's fibroblasts, achieving high accuracy in distinguishing disease subtypes.

Wnt Regulation: Exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

The paper investigates Wnt signaling by examining Axin-Dishevelled interactions and the recruitment of the SCF E3 ubiquitin ligase to the destruction complex, revealing dynamic roles of Axin and Dishevelled.

A low-cost fluorescence reader for in vitro transcription and nucleic acid detection with Cas13a

The paper develops a low-cost fluorescence reader for POCT, capable of detecting nanomolar concentrations of fluorescein and demonstrating RNA transcription and Cas13a-based RNA detection.