HIV-1 Mutants that Escape the Cytotoxic T-Lymphocytes are Defective in Viral DNA Integration
M. Balasubramaniam, S. Thapa, B.-O. Davids, A. Bryer, C. Xu, J. Shi, C. Aiken, J. Pandhare, J. R. Perilla, C. Dash
This study shows that an HIV-1 mutation escaping CTL response impairs viral DNA integration, and compensatory mutations or host factors can rescue this defect.
bioRxiv · Aug 29, 2021Microbiology