Author

E. Lyman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 8 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Approach:mechanistic / dynamical model· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

E. Sezgin· 3 shared A. Ray· 2 shared C. Eggeling· 2 shared I. Levental· 2 shared J. H. Lorent· 2 shared K. A. Jacobson· 2 shared K. R. Levental· 2 shared L. Sharp· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

E. Sezgin

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Membrane Mimetic-Dependence of GPCR Energy Landscapes

N. Thakur, A. Ray, E. Lyman, Z. Gao, K. A. Jacobson, M. T. Eddy

This study investigates how temperature affects the conformational landscape of the A2A adenosine receptor, showing drug efficacy and membrane mimetic dependence.

bioRxiv · Oct 16, 2023 · PreprintBiophysics

Varying the position of phospholipid acyl chain unsaturation modulates hopanoid and sterol ordering

A. H. N. Nguyen, L. Sharp, E. Lyman, J. P. Saenz

This study shows that hopanoids and sterols modulate lipid ordering differently based on phospholipid acyl chain unsaturation position, with cholesterol providing broader ordering effects than diplopterols.

bioRxiv · Sep 6, 2023Biophysics

Cell Membranes Sustain Phospholipid Imbalance Via Cholesterol Asymmetry

M. Doktorova, J. L. Symons, X. Zhang, H.-Y. Wang, J. Schlegel, J. H. Lorent, F. A. Heberle, E. Sezgin, E. Lyman, K. R. Levental, I. Levental

The paper reveals that mammalian plasma membranes have phospholipid imbalances due to cholesterol asymmetry, affecting membrane permeability and protein localization.

bioRxiv · Jul 30, 2023Biophysics

Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition

N. Thakur, A. Ray, L. Sharp, B. Jin, A. Duong, N. Gopal Pour, S. Obeng, A. Wijesekara, Z.-G. Gao, C. McCurdy, K. A. Jacobson, E. Lyman, M. Eddy

This study shows anionic lipids facilitate GPCR-G protein complex formation through conformational selection, with computational models supporting charge complementarity as a general mechanism.

bioRxiv · Jan 11, 2023Biophysics

Full scale structural, mechanical and dynamical properties of HIV-1 liposomes.

A. Bryer, E. Lyman, T. Reddy, J. R. Perilla

This study uses molecular dynamics simulations to analyze the structural, mechanical, and dynamical properties of HIV-1 liposomes and their relationship to lipid composition.

bioRxiv · Mar 24, 2021Biophysics

Activation of G-protein coupled receptors is thermodynamically linked to lipid solvation

A. N. Leonard, E. Lyman

The paper evaluates lipid solvation of the A2A adenosine receptor using molecular dynamics simulations and finds that unsaturated lipid chains favor the active receptor state.

bioRxiv · Aug 20, 2020Biophysics

The mammalian plasma membrane is defined by transmembrane asymmetries in lipid unsaturation, leaflet packing, and protein shape

J. H. Lorent, K. R. Levental, L. Ganesan, G. Longsworth, E. Sezgin, M. N. Doktorova, E. Lyman, I. Levental

The paper characterizes lipid and protein asymmetries in mammalian plasma membranes and shows their conservation across eukaryotes.

bioRxiv · Feb 11, 2020Cell Biology

Nanoscale dynamics of cholesterol in the cell membrane

K. A. Pinkwart, F. Schneider, M. Lukoseviciute, T. Sauka-Spengler, E. Lyman, C. Eggeling, E. Sezgin

This study uses advanced fluorescence imaging to examine cholesterol dynamics in cell membranes, finding faster diffusion in live cells compared to model membranes.

bioRxiv · May 21, 2019Biophysics

The Organization of Membranes Below 100 nm: Experimental Breakthroughs Occasion a Modeling Manifesto

E. Lyman, C. Eggeling, C.-L. Hsieh

The paper reviews experimental advances revealing membrane heterogeneity and scale dependence, and calls for simulation methods that can capture these features to better understand membrane organization.

bioRxiv · Mar 31, 2018Biophysics