C. Dash

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

Cyclophilin A Facilitates HIV-1 DNA Integration

This study shows that Cyclophilin A promotes HIV-1 integration by enhancing preintegration complex activity, revealing a new role for CypA in the viral life cycle.

Monocytes Mobilized by Gut Neurons Remodel the Enteric Nervous System

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Three Prime Repair Exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural and conformational properties.

This study identifies how TREX1 preferentially degrades unprocessed HIV-1 DNA over 3-processed DNA through kinetic, thermodynamic, and structural differences.

HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification

This study identifies that HIV-1 preintegration complex preferentially integrates viral DNA into nucleosomes with H3K36me3 modification and linker DNA.

HIV-1 Mutants that Escape the Cytotoxic T-Lymphocytes are Defective in Viral DNA Integration

This study shows that an HIV-1 mutation escaping CTL response impairs viral DNA integration, and compensatory mutations or host factors can rescue this defect.

Phycobilins as potent food bioactive broad-spectrum inhibitor compounds against Mpro and PLpro of SARS-CoV-2 and other coronaviruses: A preliminary Study

This study identifies phycobilins as potent broad-spectrum inhibitors against Mpro and PLpro proteases of SARS-CoV-2 and other coronaviruses using in silico and in vitro methods.