Author

J. Pandhare

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. Dash· 4 shared M. Balasubramaniam· 4 shared P. Prakash· 3 shared B.-O. Davids· 2 shared C. Aiken· 2 shared J. Shi· 2 shared S. Thapa· 2 shared A. Bryer· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersMicrobiology

C. Dash

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cyclophilin A Facilitates HIV-1 DNA Integration

A. Padron, R. Dwivedi, R. Chakraborty, P. Prakash, K. Kim, J. Shi, J. Ahn, J. Pandhare, J. Luban, C. Aiken, M. Balasubramaniam, C. Dash

This study shows that Cyclophilin A promotes HIV-1 integration by enhancing preintegration complex activity, revealing a new role for CypA in the viral life cycle.

bioRxiv · Jun 15, 2024 · PreprintMicrobiology

Three Prime Repair Exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural and conformational properties.

P. Prakash, P. Khodke, M. Balasubramaniam, B.-O. Davids, T. Hollis, J. Davis, J. Pandhare, B. Kumbhar, C. Dash

This study identifies how TREX1 preferentially degrades unprocessed HIV-1 DNA over 3-processed DNA through kinetic, thermodynamic, and structural differences.

bioRxiv · Mar 19, 2024Biochemistry

HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification

N. E. Sapp, N. Burge, K. Cox, S. Thapa, P. Prakash, M. Balasubramaniam, D. Christensen, M. Li, J. Linderberger, M. Kvaratskhelia, W. I. Sundquist, J. Pandhare, R. Craigie, M. G. Poirier, C. Dash

This study identifies that HIV-1 preintegration complex preferentially integrates viral DNA into nucleosomes with H3K36me3 modification and linker DNA.

bioRxiv · Feb 16, 2022 · PreprintBiochemistry

HIV-1 Mutants that Escape the Cytotoxic T-Lymphocytes are Defective in Viral DNA Integration

M. Balasubramaniam, S. Thapa, B.-O. Davids, A. Bryer, C. Xu, J. Shi, C. Aiken, J. Pandhare, J. R. Perilla, C. Dash

This study shows that an HIV-1 mutation escaping CTL response impairs viral DNA integration, and compensatory mutations or host factors can rescue this defect.

bioRxiv · Aug 29, 2021Microbiology