Author

A. Buchanan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Research Focus:clustering· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. G. Rees· 2 shared A. A. Komissarov· 1 shared A. O. Azghani· 1 shared A. P. Sergeeva· 1 shared A. Sigurdardottir· 1 shared A. Struck· 1 shared B. Honig· 1 shared B. Popovic· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

D. G. Rees

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Author profile →

4 papers

Recent·Most cited

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations

J. M. Sampson, D. A. Cannon, J. Duan, A. P. Sergeeva, J. C. K. Epstein, P. S. Katsamba, S. M. Mannepalli, F. A. Bahna, H. Adihou, S. M. Gueret, R. Gopalakrishnan, S. Geschwindner, D. G. Rees, A. Sigurdardottir, T. Wilkinson, , L. Wang

The paper benchmarks free energy perturbation calculations for predicting mutation effects on protein-protein binding affinity and introduces an automated method to improve accuracy.

bioRxiv · Apr 22, 2024Biophysics

Precision targeting of the Plasminogen Activator Inhibitor-1 mechanism increases efficacy of fibrinolytic therapy in empyema.

G. Florova, R. A. Girard, A. O. Azghani, K. Sarva, A. Buchanan, S. Karandashova, C. J. DeVera, D. Hill, M. Chamiso, K. Koenig, D. B. Cines, S. Idell, A. A. Komissarov

The paper demonstrates that targeting PAI-1 with DSP reduces the required dose of tPA/uPA in empyema treatment without bleeding complications in rabbit models.

bioRxiv · Oct 5, 2020Biochemistry

In vitro Evolution of Antibody Affinity via Insertional Mutagenesis Scanning of an Entire Antibody Variable Region

K. Skamaki, S. Emond, M. Chodorge, J. Andrews, D. G. Rees, D. Cannon, B. Popovic, A. Buchanan, R. Minter, F. Hollfelder

This paper demonstrates that insertional mutagenesis can enhance antibody affinity, achieving a 256-fold improvement in an anti-IL-13 antibody through InDel mutagenesis combined with point mutations.

bioRxiv · Apr 26, 2020Biochemistry

Exploring Integrative Analysis using the BioMedical Evidence Graph

A. Struck, B. Walsh, A. Buchanan, J. A. Lee, R. Spangler, J. Stuart, K. Ellrott

The paper introduces the BioMedical Evidence Graph (BMEG), a graph database for integrative cancer biology analysis, demonstrating its utility through various queries and comparisons with other systems.

bioRxiv · Sep 25, 2019Cancer Biology