D. Hill

Commensal bacteria inhibit viral infections via a tryptophan metabolite

The paper identifies a mechanism by which commensal bacteria inhibit viral infections through a tryptophan metabolite that activates the aryl hydrocarbon receptor.

Pervasive mislocalization of pathogenic coding variants underlying human disorders

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

Effects of mucin and DNA concentrations in airway mucus on Pseudomonas aeruginosa biofilm recalcitrance

This study investigates how mucin and DNA concentrations in airway mucus affect Pseudomonas aeruginosa biofilm mechanical properties, finding that overall mucus concentration is the main factor influencing viscoelasticity.

Elucidation of SARS-CoV-2 budding mechanisms through molecular dynamics simulations of M and E protein complexes

The paper uses molecular dynamics simulations to study SARS-CoV-2 M and E protein interactions during budding, revealing their roles in membrane curvature and planarity.

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

This paper shows that SARS-CoV-2 Spike protein causes cardiac pericyte dysfunction through CD147-mediated signaling, without infecting the cells.

Precision targeting of the Plasminogen Activator Inhibitor-1 mechanism increases efficacy of fibrinolytic therapy in empyema.

The paper demonstrates that targeting PAI-1 with DSP reduces the required dose of tPA/uPA in empyema treatment without bleeding complications in rabbit models.

Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma Cells

The paper isolates and characterizes LGR5-positive cells from human colon adenomas using organoids and RNA-sequencing, identifying correlations with CRC-specific genes.