Telomere length sensitive regulation of Interleukin Receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment
A. K. Mukherjee, S. Dutta, A. Singh, S. Sharma, S. S. Roy, A. Sengupta, M. Chatterjee, S. Vinayagamurthy, S. Bagri, D. Khanna, M. Verma, D. Soni, A. Budharaja, S. K. Bhisade, V. anand, , S. Chowdhury
The paper shows that telomere length modulates IL1R1 expression via TRF2 binding, affecting immune signaling and macrophage infiltration in TNBC.
bioRxiv · Dec 7, 2021 · PreprintCancer Biology