A. Sengupta

Synergistic phenotypic shifts during domestication promote plankton-to-biofilm transition in purple sulfur bacterium Chromatium okenii

This study shows that domestication of Chromatium okenii leads to synergistic phenotypic shifts that suppress motility and promote a transition to a sessile biofilm state.

Support Vector Machine based prediction models for drug repurposing and designing novel drugs for colorectal cancer

This study develops QSAR models and a webserver to predict novel drugs and repurpose existing ones for colorectal cancer treatment using pharmacological profiles and in-silico validation.

Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

This paper shows telomere length regulates hTERT expression by modulating TRF2 binding and PRC2-mediated repression, revealing a self-regulatory mechanism in cancer.

Activity-driven emergence of genealogical enclaves in growing bacterial colonies

The paper tracks bacterial cell lineage in growing colonies to reveal genealogical enclaves formed by activity-driven demixing.

Phytoplankton tune local pH to actively modulate circadian swimming behavior

This study shows that phytoplankton actively regulate local pH to create distinct gravitactic sub-populations, leading to irregular diel vertical migration patterns.

Motile bacteria leverage bioconvection for eco-physiological benefits in a natural aquatic environment

The paper investigates how bioconvection affects the metabolism of Chromatium okenii in Lake Cadagno, showing enhanced metabolic advantage through transcriptomic analysis.

Fibroblasts-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis

This study identifies fibroblast-derived extracellular vesicles containing SFRP1 that contribute to pulmonary fibrosis and suggests SFRP1 as a therapeutic target.

KDM6A loss sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

This study shows that KDM6A loss in AML increases sensitivity to PARP and BCL2 inhibitors, suggesting a new combination therapy approach for KDM6A-mutant AML.

Autocrine Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts

The paper identifies Sfrp1 as an autocrine inhibitor of fibroblast invasion during lung fibrosis by analyzing fibroblast states and signaling pathways in mouse lung regeneration.

Telomere length sensitive regulation of Interleukin Receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

The paper shows that telomere length modulates IL1R1 expression via TRF2 binding, affecting immune signaling and macrophage infiltration in TNBC.

Active reconfiguration of cytoplasmic lipid droplets governs migration of nutrient-limited phytoplankton

This study shows that phytoplankton use lipid droplets to biomechanically regulate migration in nutrient-limited environments.

In-vivo protein nitration and de-nitration facilitate Vibrio cholerae cell survival under anaerobic condition: Consequences of Nitrite induced protein nitration

This study shows that in vivo protein nitration and denitration in Vibrio cholerae under anaerobic conditions enhance cell survival by managing nitrite and nitrate levels.

Bistability in oxidative stress response determines the migration behavior of phytoplankton in turbulence

This study shows that bistable oxidative stress response in phytoplankton determines migration behavior in turbulence, with stress signaling triggering directional switches.

Disturbance Triggers Non-Linear Microbe-Environment Feedbacks

The paper tests a conceptual framework linking microbial communities with environmental factors and processes, finding non-linear feedbacks triggered by disturbance.

Human Telomerase Expression is under Direct Transcriptional Control of the Telomere-binding-factor TRF2

This study shows TRF2 directly represses hTERT through G-quadruplex-dependent mechanisms, linking telomere regulation to telomerase activity in normal and cancer cells.

Dark aerobic sulfide oxidation by anoxygenic phototrophs in the anoxic waters of Lake Cadagno

This study shows that Chromatium okenii drives dark aerobic sulfide oxidation in anoxic Lake Cadagno waters, challenging the assumption that aerobic respiration is rare in such environments.