M. Verma

A comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

The paper develops and validates a method to simulate speckle contrast signals for optical blood flow measurements, revealing how detector effects impact accuracy and precision.

Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism.

This study shows that reduced RPL22 expression in hematopoietic stem cells promotes leukemia by altering metabolism and increasing lipid synthesis via Lin28b.

Cellular Dynamics of Skeletal Muscle Regeneration

This study investigates skeletal muscle regeneration by tracking stem cells and reveals key cellular mechanisms in restoring tissue architecture and forming branched myofibers.

Multi-Mode Fiber-Based Speckle Contrast Optical Spectroscopy: Analysis of Speckle Statistics

This paper evaluates the use of multi-mode fiber bundles in speckle contrast optical spectroscopy to improve imaging of cerebral blood flow while distinguishing flow-based speckle from static speckle and noise.

Prioritizing landscapes to reconcile biodiversity conservation, ecosystem services, and human well-being in India

This study identifies priority landscapes in India for biodiversity conservation and ecosystem services that align with human well-being, finding that current protected areas cover only 15% of these regions.

Live visualization of endoplasmic reticulum redox potential in zebrafish embryos reveals region-specific differences

This study uses transgenic zebrafish to visualize ER redox potential in live embryos, revealing region-specific deviations from expected oxidizing states.

Telomere length sensitive regulation of Interleukin Receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

The paper shows that telomere length modulates IL1R1 expression via TRF2 binding, affecting immune signaling and macrophage infiltration in TNBC.

Heteologous saRNA-Prime, DNA Dual-Antigen-Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies

This study evaluates heterologous vaccination with two SARS-CoV-2 vaccines in mice, finding enhanced humoral and T-cell responses and broad neutralizing activity against variants.

The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice

This study evaluates a dual-antigen Ad5 vaccine delivered via subcutaneous and intranasal routes in mice, showing that combined prime-only delivery elicits strong humoral and T-cell responses against SARS-CoV-2.

Complete Protection of Nasal and Lung Airways Against SARS-CoV-2 Challenge by Antibody Plus Th1 Dominant N- and S-Specific T-Cell Responses to Subcutaneous Prime and Thermally-Stable Oral Boost Bivalent hAd5 Vaccination in an NHP Study

hAd5 spike + nucleocapsid SC prime/oral boost vaccine elicits humoral and T-cell responses and protects rhesus macaques from SARS-CoV-2 challenge.

A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses

This paper describes a bivalent hAd5 vaccine combining S-Fusion and N-ETSD antigens that elicits strong Th1-biased T-cell and neutralizing antibody responses in pre-clinical models.

Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hotspots, Functional Crosstalk and Regulatory Interactions in SARS-CoV-2

The paper analyzes SARS-CoV-2 genomic variations and host-pathogen interactions to identify mutational patterns, co-mutations, and functional implications in USA strains.

Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution

This study analyzes SARS-CoV-2 genomes from global isolates to reveal mosaic phylogeographical patterns and identify unique mutations associated with immune evasion mechanisms.

LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity

This study shows LRP5 enhances adipocyte insulin sensitivity and adipose progenitor cell fitness, with implications for obesity and aging.

Human Telomerase Expression is under Direct Transcriptional Control of the Telomere-binding-factor TRF2

This study shows TRF2 directly represses hTERT through G-quadruplex-dependent mechanisms, linking telomere regulation to telomerase activity in normal and cancer cells.

TCF7L2 plays a complex role in human adipose progenitor biology which may contribute to genetic susceptibility to type 2 diabetes.

This study investigates TCF7L2's role in adipose progenitor biology and links its genetic variation to type 2 diabetes risk through effects on adipogenesis and insulin sensitivity.