FGF-21 Conducts a Liver-Brain-Kidney Axis to Promote Renal Cell Carcinoma
Z. Li, X. Zhang, W. Zhu, C. Zhang, K. Sadak, A. A. Halberstam, J. R. Brown, C. J. Perry, A. Bunn, D. A. Braun, A. Adeniran, S. Lee, A. Wang, R. J. Perry
This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.
bioRxiv · Apr 12, 2023 · PreprintPhysiology