J. R. Brown

This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.

The paper evaluates the gut microbiome's role in predicting neoadjuvant chemotherapy response in urothelial carcinoma, finding microbial community signatures outperform clinical variables in prediction.

This study identifies ERBB4-mediated signaling as a mechanism of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms and shows that targeting ERBB signaling can restore sensitivity.

This study uses ex vivo drug sensitivity testing to identify treatment responses and vulnerabilities in chronic lymphocytic leukemia patients, showing that pan-PI3Ki and combinations with venetoclax can be effective in idelalisib-refractory/intolerant cases.

The paper reviews and extends the equal fitness paradigm to link metabolism, energy allocation, and universal rules of life across ecological and evolutionary scales.

The paper compares four RT-PCR mastermixes and three N gene assays for SARS-CoV-2 detection, finding the N2 assay most sensitive and Takara mastermix best at low detection limits.

The paper investigates the evolutionary trajectories of chronic lymphocytic leukemia cells during resistance to graft-versus-leukemia, finding distinct genetic and epigenetic dynamics post-transplant compared to chemotherapy.