Author

A. C. Dommer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Approach:deep learning· 2 Organism:human· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

L. Casalino· 4 shared R. E. Amaro· 4 shared Z. Gaieb· 4 shared E. P. Barros· 3 shared A. Bogetti· 1 shared A. Brace· 1 shared A. J. Pak· 1 shared A. M. Harbison· 1 shared

Activity by Year

2020-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersBiophysics

L. Casalino

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BiophysicsbioRxivNov 19, 2020

AI-Driven Multiscale Simulations Illuminate Mechanisms of SARS-CoV-2 Spike Dynamics

L. Casalino, A. C. Dommer, Z. Gaieb…·R. E. Amaro

This paper develops an AI-driven workflow to simulate SARS-CoV-2 spike protein dynamics, revealing glycan shield structure, spike glycans' role in infectivity, and spike-ACE2 interactions.

DOI 10.1177/10943420211006452

virusstructural biology

𝕏 PostBluesky

BiophysicsbioRxivOct 2, 2020

A Multiscale Coarse-grained Model of the SARS-CoV-2 Virion

A. Yu, A. J. Pak, P. He…·G. A. Voth

This paper develops a multiscale coarse-grained model of the SARS-CoV-2 virion using structural data and all-atom simulations to enable large-scale viral process simulations.

DOI 10.1016/j.bpj.2020.10.048

viruscryo-EM

𝕏 PostBluesky

BiophysicsbioRxivSep 16, 2020

The flexibility of ACE2 in the context of SARS-CoV-2 infection

E. P. Barros, L. Casalino, Z. Gaieb…·R. E. Amaro

This paper uses molecular dynamics simulations to study ACE2 flexibility in SARS-CoV-2 infection, finding structural dynamics that may aid viral entry and therapeutic design.

DOI 10.1016/j.bpj.2020.10.036

humanprotein structure

𝕏 PostBluesky

BiophysicsbioRxivJun 11, 2020

Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike Protein

L. Casalino, Z. Gaieb, J. Goldsmith…·R. E. Amaro

This study reveals the structural role of glycans in modulating SARS-CoV-2 spike protein conformational dynamics and ACE2 binding through molecular simulations and experiments.

DOI 10.1021/acscentsci.0c01056

humanstructural biology

𝕏 PostBluesky