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Activation of three targets by a TAL effector confers susceptibility to bacterial blight of cotton

The paper identifies a newly evolved TALE, Tal7b, that activates multiple GhSWEET genes in cotton, contributing to bacterial blight susceptibility.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

Pure Nano Genesis: Pioneering Universal Aqueous Nanostrategies from Pure Molecules to Revolutionise Diverse Applications

This paper introduces a novel method for creating stable aqueous nanoparticles from pure conjugated molecules, demonstrating their efficacy in treating various diseases in vivo.

The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

This study investigates the protective effects of eugenol on type 1 diabetes mellitus by activating the NRF2 pathway, reducing oxidative stress and apoptosis in pancreatic β cells.

Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma

The paper identifies hybrid cells in human glioma with both neuronal and glial electrophysiological and transcriptomic features using Patch-sequencing and a new computational tool.

Global variation in the ratio of sapwood to leaf area explained by optimality principles

The paper explains 60% of global variation in sapwood-to-leaf area ratio using optimality principles linking plant hydraulics and photosynthesis.

Modulation of stress granule dynamics by phosphorylation and ubiquitination in plants

This study identifies phosphorylation and ubiquitination as key regulators of TZF1 stress granule assembly in Arabidopsis.

Group size modulates kinship dynamics and selection on social traits

This study shows that group size affects kinship dynamics and age-related social behaviors in social mammals, with smaller groups promoting more extreme helping/harming behaviors, especially in younger individuals.

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

Targeting PKC alleviates iron overload in diabetes and hemochromatosis

This study shows PKC inhibition reduces iron overload in diabetes and hemochromatosis by modulating ferroportin expression and trafficking.

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

Differences in Hepatocellular Iron Metabolism Underlie Sexual Dimorphism in Hepatocyte Ferroptosis

This study identifies sex differences in hepatocyte ferroptosis, showing males are more susceptible due to differences in iron metabolism and FSP1 regulation.

A Human Breast Cell Atlas Mapping the Homeostatic Cellular Shifts in the Adult Breast

This study creates a Human Breast Cell Atlas using scRNA-seq from 55 donors, identifying 41 cell subclusters and showing how factors like age and BRCA mutations affect breast homeostasis and immune cell states.

Remote neuronal activity drives glioma infiltration via Sema4f

This study identifies callosal projection neurons as drivers of glioma infiltration through Sema4F-mediated activity-dependent signaling in mouse and human tumors.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

Early human lung immune cell development and its role in epithelial cell fate

The paper profiles lung immune cells during development using scRNAseq and identifies IL-1β's role in driving epithelial progenitor differentiation.

Identification of functional immune and neuronal tumor cells in glioma

The paper introduces SCRAM, a tool that identifies tumor-specific cell types in glioma with functional properties similar to non-tumor cells.

FGFR1 governs iron metabolism via regulating post-translational modification of IRP2 in prostate cancer cells

This study shows FGFR1 promotes prostate cancer by enhancing iron metabolism through regulation of IRP2 post-translational modification and TFR1 expression.

Single-Molecule Structure and Topology of Kinetoplast DNA Networks

This study presents the first high-resolution single-molecule analysis of kDNA network topology using AFM and simulations, revealing heterogeneous structure and buckling behavior.

A guide to sampling design for GPS-based studies of animal societies

This paper provides quantitative recommendations for GPS sampling design in animal society studies, highlighting trade-offs between coverage, duration, and frequency to improve inference robustness.

Mapping the developing human immune system across organs

This study maps the developing human immune system across organs using single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics, revealing cross-gestation and cross-organ variability and identifying prenatal B1 cells and unconventional T cell origins.

Pharmacokinetics and Pharmacodynamics of Vancomycin derivative LYSC98 in a Murine Thigh Infection Model against Staphylococcus aureus

This study evaluates the PK/PD of LYSC98 against Staphylococcus aureus in a murine model, identifying Cmax/MIC as the best predictor of efficacy.

A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche

The paper creates a spatial multi-omics lung atlas identifying novel cell types and a survival niche for IgA-secreting plasma cells in submucosal glands.

Structure and computation-guided design of a mutation-integrated trimeric RBD candidate vaccine with broad neutralization against SARS-CoV-2

This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.

Immune elicitation by sensing the conserved signature from phytocytokines and microbes via the Arabidopsis MIK2 receptor

The paper identifies MIK2 as a plant receptor that recognizes conserved peptide motifs from phytocytokines and microbial proteins, triggering immune responses through a signaling relay.

Social network architecture and the tempo of cumulative cultural evolution

This study simulates cultural trait innovation and diffusion in structured populations to show how social network architecture affects cumulative cultural evolution outcomes.

Recombinant Fc-fusion vaccine of RBD induced protection against SARS-CoV-2 in non-human primate and mice

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

Scavenger receptor A1 participates in the phagocytosis of Leptospira interrogans and leads to subsequent high inflammatory responses and bacterial dissemination in leptospirosis

This study shows that SR-A1 facilitates Leptospira phagocytosis by macrophages but also promotes bacterial dissemination and inflammation, worsening leptospirosis in mice.

Changes in nitrogen pools in the maize-soil system after urea or straw application to a typical intensive agricultural soil: A 15N tracer study

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

A Multiscale Coarse-grained Model of the SARS-CoV-2 Virion

This paper develops a multiscale coarse-grained model of the SARS-CoV-2 virion using structural data and all-atom simulations to enable large-scale viral process simulations.