A. Yu

Endothelial c-Src mediates neovascular tuft formation in Oxygen-Induced Retinopathy

This study shows that c-Src is essential for neovascular tuft formation in Oxygen-Induced Retinopathy, as its depletion reduces tuft formation without affecting cell death, proliferation, or adhesion.

A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints

This study evaluates the reproducibility and temporal evolution of FLASH and CONV irradiation effects on mice, showing FLASH sparing at late but not early time points.

A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections

This paper introduces a drug-free nasal spray that captures and neutralizes respiratory pathogens, showing high efficacy in mice against influenza.

c-Src induced vascular malformations require localised matrix degradation at focal adhesions

This study shows that c-Src activation in endothelial cells causes vascular expansion through focal adhesion signaling and localized matrix degradation, which can be inhibited to prevent abnormal vascular growth.

HYENA detects oncogenes activated by distal enhancers in cancer

HYENA identifies oncogenes, including non-coding genes, activated by enhancer hijacking in cancer using whole-genome and transcriptome sequencing data.

Phosphorylation at Ser65 modulates ubiquitin conformational dynamics

This study investigates how phosphorylation at Ser65 affects ubiquitin's conformational dynamics by identifying a stable intermediate state and its role in conformational transitions.

Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

TYMV has dual action on the plant RNA silencing defense through its VSR P69 and the host RNASE THREE LIKE1

This paper shows that TYMV uses its VSR P69 and host RTL1 to partially inhibit RNA silencing amplification, allowing virus propagation without killing the host.

Salmonella enterica serovar Typhimurium chitinases modulate the intestinal glycome and promote small intestinal invasion.

This study shows Salmonella chitinases enhance intestinal invasion by modulating host glycans, with chitinase-deficient strains showing reduced invasion and delayed dissemination.

Strain and rupture of HIV-1 capsids during uncoating

This study uses molecular dynamics simulations and cryo-ET to show HIV-1 capsids exhibit strain patterns and rupture via crack propagation along high-strain regions.

Opportunity or catastrophe? Effect of sea salt on host-parasite survival and reproduction

This study examines how increasing salinity affects host-parasite interactions in freshwater systems, finding reduced host survival and parasite transmission with higher salinity.

Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core

This study uses coarse-grained models and cryo-ET data to show that SARS-CoV-2 spike trimers cooperatively bind to ACE2 dimers, promoting S1 dissociation and exposing the fusion machinery.

The long non-coding RNA MaTAR20 promotes mammary tumor growth by regulating angiogenesis pathways

This study identifies MaTAR20 as a lncRNA that promotes mammary tumor growth by regulating angiogenesis pathways, specifically through its interaction with Tnfsf15.

A Multiscale Coarse-grained Model of the SARS-CoV-2 Virion

This paper develops a multiscale coarse-grained model of the SARS-CoV-2 virion using structural data and all-atom simulations to enable large-scale viral process simulations.

The Lonidamine Derivative H2-Gamendazole Reduces Cyst Formation in Polycystic Kidney Disease

This study shows that H2-GMZ reduces cyst formation in ADPKD by inhibiting Cl- secretion, cell proliferation, and motility in both in vitro and in vivo models.

Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states.

The paper uses SIVS and scRNA-seq to analyze T cell infiltration and residency in the GI tract during aGVHD, identifying genes associated with tissue invasiveness and TRM programming.

Atomic-scale Characterization of Mature HIV-1 Capsid Stabilization by Inositol Hexakisphosphate (IP6)

The paper uses molecular dynamics simulations to show IP6 stabilizes HIV-1 capsid pentamers over hexamers, enhancing capsid stability.

Combined use of metagenomic sequencing and host response profiling for the diagnosis of suspected sepsis.

This study combines metagenomic sequencing and host response profiling to improve sepsis diagnosis by detecting pathogens and guiding clinical decisions.

Hyaluronic acid particle hydrogels decrease cerebral atrophy and promote pro-reparative astrocyte/axonal infiltration after ischemic stroke

This study shows that HA-MAP hydrogel injection reduces cerebral atrophy and promotes pro-repair astrocyte and axonal infiltration after ischemic stroke.

Clinically-relevant cell type cross-talk identified from a human lung tumor microenvironment interactome

The paper identifies clinically relevant cell type interactions in the lung tumor microenvironment using RNA-seq data from sorted cell populations.

Supercharged Assembly: A Broad-Spectrum Mechanism of Action for Drugs that Undermine Controlled HIV-1 Viral Capsid Formation

This study uses molecular dynamics simulations to show how capsid inhibitors disrupt HIV-1 capsid assembly, leading to structural defects and disassembly, and highlights the importance of dynamic mechanisms in drug design.

Transcriptional control and exploitation of an immune-responsive family of retrotransposons in Arabidopsis

This study shows that an immune-responsive retrotransposon in Arabidopsis influences disease resistance gene expression through its LTR.