Cancer BiologybioRxivPreprint
NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates
B. Achutti Duso, E. Messuti, G. Tini…·L. Mazzarella
This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.
DOI 10.1101/2023.12.06.569572