NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates
B. Achutti Duso, E. Messuti, G. Tini, E. Bonetti, A. Castiglioni, G. Frige, G. Ciossani, S. Monzani, C. Soriani, D. Khuntsariya, N. Roda, A. Polazzi, M. R. Ippolito, E. Gavilan Dorronzoro, E. Mane, , L. Mazzarella
This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.
bioRxiv · Dec 6, 2023 · PreprintCancer Biology