Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy
E. Hoogenboezem, S. S. Patel, A. Cavnar, J. Lo, L. Babb, N. Francini, P. Patil, J. Colazo, D. L. Michell, V. Sanchez, J. McCune, J. Ma, C. DeJulius, L. Lee, J. Rosch, , C. Duvall
This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.
bioRxiv · Feb 14, 2023 · PreprintBioengineering