J. Lo

Conditional CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors

This study develops CAR T cells specific to oncofetal chondroitin sulfate, demonstrating their ability to target and eliminate tumor cells in vitro and improve survival in vivo.

Matrix architecture and mechanics regulate myofibril organization, costamere assembly, and contractility of engineered myocardial microtissues

This study investigates how matrix stiffness and alignment affect the structure and contractility of engineered myocardial tissues made from iPSC-derived cardiomyocytes.

Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury

This study compares systemic and cardiac inflammatory responses to injury in mice and zebrafish using single-cell transcriptomics, revealing distinct monocyte/macrophage transcriptional clusters and divergent responses between species.

Loss of daylength sensitivity by splice site mutation in Cannabis

The paper identifies a splice site mutation in CsPRR37 as the cause of photoperiod insensitivity in auto-flowering Cannabis sativa.

Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

An oral protein cocktail therapeutic for C. difficile infection

This paper describes an oral protein cocktail, LMN-201, for C. difficile infection, showing it achieves high cure rates and validates spirulina as a delivery platform.

T-bet fate mapping identifies a novel ILC1-ILC2 subset in vivo

The paper identifies a novel ILC1-ILC2 subset using T-bet fate mapping and shows its dependence on T-bet and cytokine expression capabilities.

CpG-creating Mutations are Costly in Many Human Viruses

The paper examines the cost of CpG-creating mutations in various human viruses using existing genomic data and finds they are generally costly.