S. S. Patel

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

This study reports cryo-EM structures of yeast mitochondrial RNA polymerase initiation complexes, revealing the stepwise process of transcription initiation and the role of structural changes in RNA synthesis.

This study identifies a proofreading mechanism in RIG-I that uses the CARDs-Helicase Linker to gate RNA specificity and stabilize interactions, preventing non-specific RNA engagement.

The paper introduces tyramide-conjugated DNA barcodes for multiparametric imaging, enabling rapid antibody panel development without modifying primary antibodies.

The paper uses cryo-EM to reveal steps of transcription initiation by yeast mitochondrial RNA polymerase, including promoter melting, template alignment, and abortive synthesis mechanisms.

This study identifies autoinhibitory mechanisms in Mtf1 and TFB2M where the C-tail region regulates DNA binding activity through intramolecular interactions, which are relieved by RNA polymerase interaction.

This paper identifies Kupffer cell release of platelet activating factor (PAF) as a key driver of nanocarrier toxicity and shows that PAFR inhibition prevents dose-limiting toxicities in mice.

This study investigates the conformational dynamics of yeast mitochondrial transcription initiation using single-molecule techniques, revealing dynamic transitions and backtracking behavior.

The paper identifies a novel lncRNA, Neev, expressed in regenerating earthworm segments and proposes it functions as a miRNA sponge to regulate chitin synthesis during regeneration.

The paper shows mitochondrial RNA polymerases in yeast and human cells efficiently cap RNA with NAD+ and NADH, linking metabolism to mitochondrial gene expression.

The paper measures the rate of evolution of postmating-prezygotic reproductive isolation in Drosophila and finds it evolves faster than hybrid inviability but slower than premating isolation.