Author

A. Chandrasekaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 2 Approach:simulation· 1 Approach:statistical model· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

P. Rangamani· 3 shared E. M. Lafer· 2 shared J. C. Stachowiak· 2 shared K. Graham· 2 shared L. Wang· 2 shared A. Clarke· 1 shared A. Ladak· 1 shared E. Giniger· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiophysics

P. Rangamani

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Author profile →

4 papers

Recent·Most cited

Liquid-like condensates mediate competition between actin branching and bundling

K. Graham, A. Chandrasekaran, L. Wang, N. Yang, E. M. Lafer, P. Rangamani, J. C. Stachowiak

This study shows that liquid-like condensates containing both actin branching and bundling proteins can modulate the competition between these processes, leading to organized actin structures similar to those in migrating cells.

Proceedings of the National Academy of Sciences · Jan 11, 2024Peer-reviewedBiophysics

Kinetic trapping organizes actin filaments within liquid-like protein droplets

A. Chandrasekaran, K. Graham, J. Stachowiak, P. Rangamani

This study uses computational modeling and experiments to show that kinetic trapping of actin filaments in VASP droplets leads to different network architectures like shells and rings.

bioRxiv · May 26, 2023Biophysics

Computational simulations reveal that Abl activity controls cohesiveness of actin networks in growth cones

A. Chandrasekaran, A. Clarke, P. G. McQueen, H.-Y. Fang, G. A. Papoian, E. Giniger

The paper uses computational simulations to show that Abl activity regulates actin network cohesiveness in axons by modulating Arp2/3 activity.

Molecular Biology of the Cell · Sep 15, 2022Peer-reviewedCell Biology

Liquid-like assembly of VASP drives actin polymerization and bundling

K. D. Graham, A. Chandrasekaran, L. Wang, A. Ladak, E. M. Lafer, P. Rangamani, J. C. Stachowiak

This study shows VASP forms liquid-like droplets that drive actin polymerization and bundling by creating actin-rich rings that transition into linear bundles.

bioRxiv · May 9, 2022Biophysics