Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer
R. Kumar, S. Deshpande, L. M. Sewall, G. Ozorowski, C. A. Cottrell, W.-H. Lee, L. G. Holden, S. T. Richey, A. Chandrawacar, K. Dhiman, A. Ashish, V. Kumar, S. Ahmed, N. Hingankar, N. Kumar, , J. Bhattacharya
This study shows that immunization with a thermostable HIV-1 clade C Env trimer induces potent autologous neutralizing antibodies in rabbits, with distinct epitope specificity compared to natural infection.
PLOS Pathogens · Apr 7, 2021Peer-reviewedImmunology