Author

J. Bhattacharya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Immunology· 3 Biophysics· 1 Cancer Biology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:imaging· 2

Frequent Co-Authors

N. Hingankar· 4 shared S. Deshpande· 4 shared D. Sok· 3 shared G. A. Gusarova· 3 shared M. N. Islam· 3 shared M. Y. Ansari· 3 shared P. Das· 3 shared S. Bhattacharya· 3 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersImmunology

N. Hingankar

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Macrophage-specific lipid nanoparticle therapy blocks the lungs mechanosensitive immunity due to macrophage-epithelial interactions

L. Mthunzi, M. N. Islam, G. A. Gusarova, S. Bhattacharya, B. Karolewski, J. Bhattacharya

The paper shows that macrophage-specific lipid nanoparticle therapy blocks lung mechanosensitive immunity by inhibiting Ca2+ responses and TNF secretion in alveolar macrophages.

bioRxiv · May 24, 2023 · PreprintPhysiology

Deciphering drug response and phenotypic heterogeneity of cancer cells using gene ensembles of regulatory units defined by chromatin domains

N. Pandey, M. Sharma, A. Mathur, G. A. Nzelu, M. Hakimullah, I. P. Jha, O. Chandra, S. Mishra, J. Bhattacharya, A. Sharma, R. Foo, K. S. Sandhu, A. Mandoli, R. DasGupta, V. KUMAR

The paper analyzes the relationship between TAD activity and drug response in cancer cells and patients, finding stronger correlations with TADs than individual genes.

bioRxiv · Jan 15, 2023 · PreprintCancer Biology

High resolution cryo-EM structures of two potently SARS-CoV-2 neutralizing monoclonal antibodies of same donor origin that vary in neutralizing Omicron variants

C. F. Rencilin, M. Y. Ansari, A. Chatterjee, S. Deshpande, S. Mukherjee, R. Singh, S. Jayatheertha, P. M. Reddy, P. Das, N. Hingankar, D. Rathore, R. Varadarajan, J. Bhattacharya, S. Dutta

The paper presents high-resolution cryo-EM structures of two SARS-CoV-2 neutralizing mAbs from the same donor, showing differences in their binding to Omicron variants and conformational changes in the spike protein.

bioRxiv · Dec 3, 2022 · PreprintBiophysics

Ancestral SARS-CoV-2 driven antibody repertoire diversity in an unvaccinated individual correlates with expanded neutralization breadth

S. Deshpande, M. Y. Ansari, J. Sutar, P. Das, N. Hingankar, S. Mukherjee, P. Jayal, S. Singh, A. Anantharaj, J. Singh, S. Chattopadhyay, S. Raghavan, M. Gosain, S. Chauhan, S. Shrivas, , J. Bhattacharya

The paper examines antibody diversity in an unvaccinated SARS-CoV-2 infected individual, finding that post-vaccination neutralization breadth against Omicron variants is comparable to vaccinated individuals and breakthrough infections.

bioRxiv · Oct 19, 2022Immunology

Rescue of alveolar wall liquid secretion blocks fatal lung injury by influenza-staphylococcal coinfection

S. Tang, A. C. De Jesus, D. Chavez, S. Suthakaran, S. K. L. Moore, R. Rathnasinghe, M. Schotsaert, J. Bhattacharya, J. L. Hook

This study shows that influenza virus inhibits alveolar wall liquid secretion, promoting fatal lung injury from staphylococcal infection, and that restoring this secretion protects against lung damage.

bioRxiv · Jul 7, 2022Physiology

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

N. Hingankar, S. Deshpande, P. Das, Z. A. Rizvi, A. Burns, S. Barman, F. Zhao, M. Y. Ansari, S. Mukherjee, J. L. Torres, S. Chattopadhyay, F. Mehdi, J. Sutar, D. K. Rathore, K. Pargai, , J. Bhattacharya

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

bioRxiv · Dec 25, 2021Immunology

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

R. Kumar, S. Deshpande, L. M. Sewall, G. Ozorowski, C. A. Cottrell, W.-H. Lee, L. G. Holden, S. T. Richey, A. Chandrawacar, K. Dhiman, A. Ashish, V. Kumar, S. Ahmed, N. Hingankar, N. Kumar, , J. Bhattacharya

This study shows that immunization with a thermostable HIV-1 clade C Env trimer induces potent autologous neutralizing antibodies in rabbits, with distinct epitope specificity compared to natural infection.

PLOS Pathogens · Apr 7, 2021Peer-reviewedImmunology

Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury

G. A. Gusarova, S. Das, M. N. Islam, K. Westphalen, G. Jin, I. O. Shmarakov, L. Li, S. Bhattacharya, J. Bhattacharya

The paper shows that exogenous V12Rac1 enhances alveolar F-actin and prevents TNFR1 surge, reducing mortality in ALI caused by LPS or Pseudomonas aeruginosa.

bioRxiv · Jan 20, 2021Physiology

The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS

M. N. Islam, G. A. Gusarova, S. R. Das, L. Li, E. Monma, M. Anjaneyulu, E. Owusu-Ansah, S. Bhattacharya, J. Bhattacharya

The paper shows that mitochondrial Ca2+ uniporter (MCU) expression in alveolar type 2 cells determines ARDS severity by affecting Ca2+ buffering capacity.

bioRxiv · Jan 18, 2021 · PreprintPhysiology

Dynamics of the COVID -19 Related Publications

B. Sarkar, A. Munshi, B. Ghosh, T. Ganesh, A. Manikandan, S. S. Biswal, T. Sahid, R. B, S. Sengupta, S. Roychaowdhary, J. Bhattacharya, M. Gazi, A. De, K. George, T. Ghosh, , B. K. Mohanti

This paper analyzes the dynamics of COVID-19 related publications across PubMed, Elsevier, and ResearchGate, finding rapid growth in publication rates and geographic author distribution.

bioRxiv · Aug 5, 2020 · PreprintScientific Communication & Education