S. Deshpande

Phase Separation and Ageing of Glycine-Rich Protein from Tick Adhesive

This study investigates the phase separation and ageing of glycine-rich protein from tick saliva, showing it forms biomolecular condensates and undergoes liquid-to-gel transitions.

Sex-specific Proximal Tubular Cell differentiation pathways identified by single-nucleus RNA

This study identifies sex-specific differentiation pathways in proximal tubular cells using single-nucleus RNA sequencing in mice.

Inhibition of the DENV2 and ZIKV RNA polymerases by Galidesivir triphosphate measured using a continuous fluorescence assay

This paper measures the inhibition of DENV2 and ZIKV RNA polymerases by Galidesivir triphosphate using a continuous fluorescence assay, finding it equipotent against both with IC50 values of 42 and 47 M.

High resolution cryo-EM structures of two potently SARS-CoV-2 neutralizing monoclonal antibodies of same donor origin that vary in neutralizing Omicron variants

The paper presents high-resolution cryo-EM structures of two SARS-CoV-2 neutralizing mAbs from the same donor, showing differences in their binding to Omicron variants and conformational changes in the spike protein.

Ancestral SARS-CoV-2 driven antibody repertoire diversity in an unvaccinated individual correlates with expanded neutralization breadth

The paper examines antibody diversity in an unvaccinated SARS-CoV-2 infected individual, finding that post-vaccination neutralization breadth against Omicron variants is comparable to vaccinated individuals and breakthrough infections.

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

TIAToolbox: An End-to-End Toolbox for Advanced Tissue Image Analytics

TIAToolbox provides an end-to-end Python toolbox for computational pathology, enabling efficient and accessible use of deep learning algorithms for tissue image analysis.

Actinosomes: condensate-templated proteinaceous containers for engineering synthetic cells

This paper introduces actinosomes, proteinaceous containers formed via biomolecular condensates and actin polymerization, demonstrating their use as bioreactors for protein synthesis.

Designing Biological Micro-Sensors with Chiral Nematic Liquid Crystal Droplets

This paper designs chiral nematic liquid crystal droplets as micro-sensors for detecting biological amphiphiles, showing unique optical responses and in vivo biosensing in zebrafish.

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

This study shows that immunization with a thermostable HIV-1 clade C Env trimer induces potent autologous neutralizing antibodies in rabbits, with distinct epitope specificity compared to natural infection.

Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

This study shows that mitochondrial β-oxidation removes oxylipins during bacterial inflammation, with CPT1 playing a key role, and identifies associated genetic upregulation in human sepsis.

Microhomology-mediated end joining drives complex rearrangements and over expression of MYC and PVT1 in multiple myeloma

The paper identifies MYC rearrangements in multiple myeloma, showing they are complex and linked to overexpression of MYC and PVT1 through distinct DNA repair mechanisms.

An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes

The paper develops a microfluidic platform to measure drug permeability across biomimetic liposome membranes, demonstrating improved control and yield compared to existing methods.