ImmunologybioRxiv
Conditional Antibody Expression to Avoid Central B Cell Deletion in a Humanized HIV-1 Vaccine Mouse Models
M. Tian, K. McGovern, H.-L. Cheng…·F. W. Alt
This paper develops a conditional expression strategy to enable mature B cell expression of bnAb precursors in transgenic mice, overcoming developmental blocks caused by bnAb properties.
DOI 10.1073/pnas.1921996117