Author

A. Claessens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:plant (other)· 2 Assay:whole-genome sequencing· 2 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

L. B. Stewart· 3 shared A. Amambua-Ngwa· 2 shared D. J. Conway· 2 shared D. P. Kwiatkowski· 2 shared E. Drury· 2 shared G. A. Awandare· 2 shared A. Barcons-Simon· 1 shared A. Claes· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

L. B. Stewart

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Higher multiplication rates of Plasmodium falciparum in isolates from hospital cases compared with community infections

L. B. Stewart, E. L. Escolar, J. Philpott, A. Claessens, A. Amambua-Ngwa, D. Conway

This study compares Plasmodium falciparum multiplication rates between hospital and community infections, finding higher rates in hospital isolates and a positive correlation with parasitaemia.

bioRxiv · May 2, 2024 · PreprintMicrobiology

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

H. Belda, D. Bradley, E. Christodoulou, S. D. Nofal, M. Broncel, D. A. Jones, H. Davies, M. T. Bertran, A. G. Purkiss, R. W. Ogrodowicz, D. Joshi, N. O'Reilly, L. Walport, A. Claessens, A. Powell, , M. Treeck

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

bioRxiv · Feb 22, 2024 · PreprintMicrobiology

RNA polymerase III is involved in regulating Plasmodium falciparum virulence

G. M. Diffendall, A. Claes, A. Barcons-Simon, P. Nyarko, F. Dingli, M. Santos, D. Loew, A. Claessens, A. Scherf

The paper shows RNA polymerase III regulates Plasmodium falciparum virulence by controlling cytoadhesion and responding to external stimuli in asymptomatic infections.

bioRxiv · Jul 18, 2023Microbiology

Genomic variation during culture-adaptation of genetically complex Plasmodium falciparum clinical isolates

A. Claessens, L. B. Stewart, E. Drury, A. D. Ahouidi, A. Amambua-Ngwa, M. Diakite, D. P. Kwiatkowski, G. A. Awandare, D. J. Conway

The paper analyzes genomic variation in Plasmodium falciparum clinical isolates during culture adaptation, finding that some isolates fix to single genotypes while others retain diversity, with loss-of-function mutants emerging in multiple-genotype infections.

bioRxiv · Sep 14, 2022 · PreprintMicrobiology

Intrinsic multiplication rate variation and plasticity of human blood stage malaria parasites

L. B. Stewart, O. Diez-Ingelmo, A. Claessens, J. Abugri, R. Pearson, S. Goncalves, E. Drury, D. P. Kwiatkowski, G. A. Awandare, D. J. Conway

The paper shows that variation in the multiplication rate of Plasmodium falciparum correlates with infection intensity and virulence in human malaria.

Communications Biology · Oct 28, 2020Peer-reviewedMicrobiology