M. Treeck

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but not linked to sexual commitment

The substrate quality of CK2 target sites has a determinant role on their function and evolution

The paper investigates how substrate quality affects the function and evolution of CK2 phosphosites, showing that optimal sites are more conserved and functionally important than minimal ones.

PerTurboID: A targeted in situ method to measure changes in a local protein environment reveals the impact of kinase deletion on cytoadhesion in malaria causing parasites

PerTurboID measures changes in local protein environments caused by kinase deletion in malaria parasites, revealing FIKK4.1's role in regulating PfEMP1 surface levels.

Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

This study identifies CDPK1 targets in Toxoplasma gondii, revealing a trafficking adaptor complex that regulates microneme exocytosis and host cell invasion.

A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma stimulated human cells

The paper identifies a heterotrimeric complex of Toxoplasma proteins that enhances parasite survival in IFNγ-activated human cells.

PfHDAC1 is an essential regulator of parasite asexual growth with its altered genomic occupancy and activity associated with artemisinin drug resistance in Plasmodium falciparum

This study identifies PfHDAC1 as a critical regulator of Plasmodium falciparum growth and drug resistance, showing its activity and genomic occupancy change with artemisinin exposure.

Toxoplasma gondii ROP1 subverts murine and human innate immune restriction

The paper identifies 22 secreted proteins contributing to Toxoplasma gondii growth in vivo and shows ROP1's role in evading murine and human innate immunity.

A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in Toxoplasma gondii

The paper identifies a positive feedback loop linking calcium, cyclic nucleotide, and lipid signaling in Toxoplasma gondii during egress.

GDV1 C-terminal truncation of 39 amino acids disrupts sexual commitment in Plasmodium falciparum

This study identifies a C-terminal truncation mutation in GDV1 that disrupts sexual commitment in Plasmodium falciparum by destabilizing the protein, despite normal nuclear import and HP1 interaction.

Gliding motility of Plasmodium merozoites

This study shows Plasmodium merozoites can perform gliding motility, a previously unobserved movement essential for translocation across host cells before invasion.

Differential protein phosphorylation affects the localisation of two secreted Toxoplasma proteins and is widespread during stage conversion

This paper investigates the role of phosphorylation in regulating the localization of two secreted Toxoplasma proteins during stage conversion and identifies widespread differential phosphorylation of secreted proteins.

Global profiling of myristoylation in Toxoplasma gondii reveals key roles for lipidation in CDPK1 and MIC7 function

The paper identifies 65 myristoylated proteins in Toxoplasma gondii, highlighting roles for myristoylation in CDPK1 signaling and MIC7 function during host cell invasion.

Differential requirements of cyclase associated protein (CAP) for actin turnover during the lytic cycle of Toxoplasma gondii

This study investigates the role of cyclase-associated protein (CAP) in actin turnover during the Toxoplasma gondii lytic cycle, finding differential requirements for CAP in cell-cell communication and residual body formation.

A divergent kinase lacking the glycine-rich loop regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole

The paper identifies WNG1, a divergent kinase in Toxoplasma, that regulates PV membrane ultrastructure through phosphorylation of PV-resident proteins.