D. Bradley

Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

The paper shows that mutations in protein binding domains, combined with regulatory divergence, determine the fate of gene duplicates in a protein interaction network.

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

Parallel nonfunctionalization of CK1δ/ϵ kinase ohnologs following a whole-genome duplication event

The paper investigates the evolution of HRR25 ohnologs after a whole-genome duplication in yeast, finding that nonfunctionalization, not subfunctionalization, is the main trend.

The substrate quality of CK2 target sites has a determinant role on their function and evolution

The paper investigates how substrate quality affects the function and evolution of CK2 phosphosites, showing that optimal sites are more conserved and functionally important than minimal ones.

Multiple behavioral mechanisms shape development in a highly social cichlid fish

The paper investigates how early-life social experiences affect adult behavior and stress responses in Astatotilapia burtoni cichlid fish, finding distinct behavioral syndromes linked to social partner numbers and group stability.

Dissection of the role of a SH3 domain in the evolution of binding preference of paralogous proteins

This study investigates how SH3 domains of paralogous yeast myosins evolved their binding preferences, finding that differences in interactions are not due to the SH3 domains themselves but to context-dependent factors.

The making of cauliflowers: the story of unsuccessful flowers

The paper investigates how cauliflowers and Romanesco develop through hysteresis in floral networks and mutations affecting meristem growth.

Evolution of protein kinase substrate recognition at the active site

The paper investigates the evolution of kinase substrate recognition, showing early sequence variation in specificity residues and stability of specificity in recent duplications, with phosphorylation motifs broadly distributed in eukaryotes.

Global analysis of specificity determinants in eukaryotic protein kinases

The paper identifies 30 putative specificity determinant residues in protein kinases and shows their conservation and mutation patterns in cancer and evolution.