M. Broncel

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

PerTurboID: A targeted in situ method to measure changes in a local protein environment reveals the impact of kinase deletion on cytoadhesion in malaria causing parasites

PerTurboID measures changes in local protein environments caused by kinase deletion in malaria parasites, revealing FIKK4.1's role in regulating PfEMP1 surface levels.

Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

This study identifies CDPK1 targets in Toxoplasma gondii, revealing a trafficking adaptor complex that regulates microneme exocytosis and host cell invasion.

Toxoplasma gondii ROP1 subverts murine and human innate immune restriction

The paper identifies 22 secreted proteins contributing to Toxoplasma gondii growth in vivo and shows ROP1's role in evading murine and human innate immunity.

A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in Toxoplasma gondii

The paper identifies a positive feedback loop linking calcium, cyclic nucleotide, and lipid signaling in Toxoplasma gondii during egress.

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

This study identifies ER-export and ARFRP1/AP-1-dependent lysosomal delivery of SARS-CoV-2 Envelope as critical for viral replication and release.

Differential protein phosphorylation affects the localisation of two secreted Toxoplasma proteins and is widespread during stage conversion

This paper investigates the role of phosphorylation in regulating the localization of two secreted Toxoplasma proteins during stage conversion and identifies widespread differential phosphorylation of secreted proteins.

Global profiling of myristoylation in Toxoplasma gondii reveals key roles for lipidation in CDPK1 and MIC7 function

The paper identifies 65 myristoylated proteins in Toxoplasma gondii, highlighting roles for myristoylation in CDPK1 signaling and MIC7 function during host cell invasion.

A divergent kinase lacking the glycine-rich loop regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole

The paper identifies WNG1, a divergent kinase in Toxoplasma, that regulates PV membrane ultrastructure through phosphorylation of PV-resident proteins.