Micrococcin cysteine-to-thiazole conversion through transient interactions between a scaffolding protein and two modification enzymes
D. G. Calvopina-Chavez, D. M. Bursey, Y.-J. Tseng…·J. S. Griffitts
The paper identifies key interactions in the enzymatic complex responsible for converting cysteine to thiazole in micrococcin biosynthesis, revealing a dynamic mechanism involving transient associations between scaffold and modifying enzymes.