Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics
J. L. Rose, S. Srinivasan, W. Yao, S. Seth, M. Peoples, A. Machado, C.-Y. Li, I. L. Ho, J. J. Lee, P. A. Guerrero, E. Kim, M. Syed, J. R. Daniele, A. Deem, M. Kim, , G. F. Draetta
This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.
bioRxiv · Sep 17, 2020 · PreprintCancer Biology