A. Machado

Alterations of Pleiotropic Neuropeptide-Receptor gene couples in Cetacea

The paper examines neuropeptide-receptor gene alterations in cetaceans, finding species-specific mutations and gene loss linked to their unique physiological adaptations.

Genetic legacies of mega-landslides: cycles of isolation and contact across flank collapses in an oceanic island

The paper uses genome-wide data to show that mega-landslides on Tenerife caused cyclical range fragmentation and secondary contact in weevils, mediated by Quaternary climate oscillations.

Integrative reappraisal of the Amazonian nurse frog Allobates gasconi (Morales 2002) based on topotypical data, with implications for the systematics and taxonomy of a large species complex

This paper redescribes the Amazonian nurse frog Allobates gasconi using topotypical specimens and integrates morphology and bioacoustic data to clarify its phylogenetic placement and taxonomy.

Neutralizing antibody-independent immunity to SARS-CoV-2 in hamsters and hACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion protein

This study shows that a RBD/Nucleocapsid fusion protein induces strong T cell responses and protects against SARS-CoV-2 without neutralizing antibodies in hamsters and hACE-2 mice.

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics

This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.

Neutrophil Extracellular Traps contribute to the pathogenesis of leprosy type 2 reactions

This study investigates the role of neutrophil extracellular traps (NETs) in the pathogenesis of leprosy type 2 reactions and shows that thalidomide treatment reduces NET formation.

Identification of a novel Nucleobase-Ascorbate Transporter family member in fish and amphibians

The paper identifies a new NAT family member, Slc23a5, in fish and amphibians, clarifies its evolutionary relationships, and suggests uric acid as its preferred substrate.